IL36RN and psoriasis 14, pustular: The GPP transcriptome is highly associated with genes of the innate immune system, although it shares characteristics of plaque psoriasis.18, 23 The expression levels of IL-1β, IL-1RN, IL-36α, IL-36β, IL-36γ and IL-36Ra increase in GPP and plaque psoriasis when compared to normal skin, being more intense in the pustular form.18, 23 Increased signaling for IL-1 and IL-36 in GPP is related to a significant increase in the expression of chemotactic substances to neutrophils (CXCL1, CXCL2 and CXCL8).23