VGF is related to synaptic function, and a strong correlation (rho = 0.70) between VGF and NPTX2 levels was previously observed in patients with DLB and AD by Boiten et al. 2020 [51], which is in concordance with the strong correlation (rho = 0.83) we observed in this FTD cohort. This evidence concerns the gene NPTX2 and Alzheimer disease.