Among the proteins closely associated with the response or metabolism of PCs, PEs, LPCs, LPEs, SMs, Cer, DGs, TGs and cholesterol in NSCLC patients, ALDOC, PRDX6, COL6A1, TUBA1B, TXN, DSG2, CST3, PCSK9, and ANGPTL3 were involved in the regulation of glycerophospholipid metabolism, cell adhesion, proliferation and division, oxidative stress reaction, apoptosis, cholesterol homeostasis and the clearance of plasma TGs. The gene discussed is DSG2; the disease is non-small cell lung carcinoma.