Among the proteins closely associated with the response or metabolism of PCs, PEs, LPCs, LPEs, SMs, Cer, DGs, TGs and cholesterol in NSCLC patients, ALDOC, PRDX6, COL6A1, TUBA1B, TXN, DSG2, CST3, PCSK9, and ANGPTL3 were involved in the regulation of glycerophospholipid metabolism, cell adhesion, proliferation and division, oxidative stress reaction, apoptosis, cholesterol homeostasis and the clearance of plasma TGs. This evidence concerns the gene PCSK9 and non-small cell lung carcinoma.