Correlation analysis revealed that differentially expressed proteins such as ALDOC, COL6A1, TUBA1B, TXN, DSG2, and CST3 were closely associated with the response of differential lipids such as PCs, PEs, LPCs, LPEs, SMs, Cer, DGs, TGs and cholesterol between NSCLC patients and healthy controls. The gene discussed is DSG2; the disease is non-small cell lung carcinoma.