Correlation analysis revealed that differentially expressed proteins such as ALDOC, COL6A1, TUBA1B, TXN, DSG2, and CST3 were closely associated with the response of differential lipids such as PCs, PEs, LPCs, LPEs, SMs, Cer, DGs, TGs and cholesterol between NSCLC patients and healthy controls. Here, COL6A1 is linked to non-small cell lung carcinoma.