CD4 and cancer: In a very recent study, Liu et al. [43] using a Cre-lox system, demonstrated that ablation of TGFβRII in CD4+ T-cells promotes tumor tissue healing and halts cancer progression, while in a back to back publication Li et al. [44] showed that blocking TGFβ signaling in CD4+ T-cells via Cre-lox system remodels the tumor microenvironment and restrains cancer progression.