In premature phases of tumorigenesis, TGFβ acts as a tumor suppressor [39], whereas during progressed tumor immunoediting [40] cancer cells become resistant to the signaling and antitumor activity of this cytokine and in late stages, they gain genomic mutations which turn TGFβ to a tumor promoting agent [7, 41]. Here, TGFB1 is linked to neoplasm.