While attaching to the lymph-endothelial cell monolayers, CCID is considered as a tumor intravasation process and it seems that generation of 12(S)-HETE by 15-LOX-1 under NF-κB regulation can facilitate CCID and attachment of breast cancer cells to the lymph-endothelial cells [67]. The gene discussed is OLR1; the disease is neoplasm.