GPX4 and neoplasm: It was shown that glutathione peroxidase 4 (GPX4) as a protective enzyme against lipid peroxidation as well as 15-LOX can induce nuclear factor erythroid-2 like 2 (NFE2L2) (Nrf2) as a regulator of antioxidant response in tumor cells that suppress ferroptosis and contributes to tumor cell chemoresistance [79].