In the most relevant study, Xinghan Wu et all demonstrated that inhibition of Glycogen synthase kinase-3β (GSK-3β) resulted in decreased ROS and malondialdehyde (MDA) level through activation of GPX4 and inhibition of 15-LOX that blocked ferroptosis in MCF-7, MDA-MB-231 breast cancer cells. This evidence concerns the gene ALOX15 and breast carcinoma.