VWF and von Willebrand disease 3: Mutations of C2739Y[5], C2754W[7, 8], C2804Y[6], and C2806R[9] have also been proven to cause type 3 VWD phenotype, indicating a critical role of disulfide bonds Cys2739-Cys2788, Cys2750-Cys2804, and Cys2754-Cys2806 in VWF multimerization and secretion.