VWF and von Willebrand disease 3: Based on our new finding of the mutation of C2724Y in new family of type 3 VWD, all of the four intrachain disulfide bonds (Cys2724-Cys2774, Cys2739-Cys2788, Cys2750-Cys2804, and Cys2754-Cys2806) in CK monomer are critical for VWF dimerization and secretion, the disruption of any of these disulfide bonds may lead to the significant reduction of VWF antigen in plasma and development of type 3 VWD.