In addition, utilization of the anti-PI3K compound ZsTK474 in animals following experimental stroke blunted gene expression of Tnf-α, Il-1β and Il-6 in the injured brain and induced a doubling of anti-inflammatory factors during the first 48 h after injury, while neuronal damage was halved compared to non-treated stroke animals [181]. The gene discussed is IL6; the disease is stroke disorder.