As shown in Fig. 5, the SPOP expression of adjacent tissue was significantly higher than that in cancer tissue of prostate (RR 1.73, 95% CI 1.19–2.51, I2  = 74%, random effect model, 3 comparisons, 230 cases) and liver cancer (RR 1.48, 95% CI 1.25–1.76, I2  = 45%, fix effect model, 2 comparisons, 184 cases). This evidence concerns the gene SPOP and liver cancer.