However, among these cancers, in consideration of RR value or fix effect model, we found that the SPOP expression in adjacent tissue was also higher than that in cancer tissue in gastric cancer (RR 2.40, 95% CI 1.97–2.92, fix effect model), lung cancer (RR 5.29, 95% CI 2.85–9.83, fix effect model) and colorectal cancer (RR 1.55, 95% CI 1.31–1.84, fix effect model). This evidence concerns the gene SPOP and cancer.