METTL1 and central nervous system cancer: To explore the potential molecular mechanism of METTL1 in glioma, pathway and functional enrichment analyses were performed based on the expression of METTL1. As shown in Fig. 8, functions, such as cell cycle, DNA replication, and epithelial-mesenchymal transition, were enriched, while pathways, such as p53, MAPK, IL6-JAK-STAT3, and IL2-STAT5 signaling were enriched (Table 1).