ANGPTL3 and hypobetalipoproteinemia: Individuals with more benign disorders of low apoB, who usually do not develop fat soluble vitamin deficiencies, such as patients with Familial Hypobetalipoproteinemia (FHBL) due to heterozygous mutations in apoB or Familial Combined Hypolipidemia due to mutations in ANGPTL3, can also have low NonHDL-C and TG, but they usually have values outside the range we used to define Type VI [28].