(1) Ectopic expression of UBE2T significantly promotes the growth and clonogenic survival of LUAD cells, which is similar to a previous study [13], but it can be reversed by NEDD4L overexpression; (2) siRNA-based depletion of NEDD4L promotes the growth and clonogenic survival of LUAD cells, which is abrogated by simultaneous UBE2T depletion; (3) NEDD4L is down-regulated in lung cancer tissues and high levels of NEDD4L predicts a better patient survival, whose results are consistent with previous studies [25, 26]. The gene discussed is UBE2T; the disease is lung cancer.