Finally, IHC staining of tumor tissues revealed that UBE2T-expressing tumor had increased proliferation index (increased Ki-67 and decreased P21), reduced apoptosis index (C-Cas3) and increased p-AKT expression, which was abrogated by simultaneous transfection of HA-NEDD4L (Fig. 5E). This evidence concerns the gene MKI67 and neoplasm.