GATA3 and asthma: Some scholars found that in an OVA-induced mouse asthma model, Que could regulate the expression of the T-bet and GATA-3 genes and affect the production of Th1/Th2 cytokines, resulting in a decrease in the IL-4 level of Th2 cytokines and an increase in the IFN-γ level of Th1 cytokines [12].