The only exception was the forward feature selection method applied on all features together, which resulted selecting statistically significantly less features than our approach combined with FFS, but the only one that did not identify the relationship between the DNMT1 and CHEK1 genes, despite it has been confirmed in both OV cancer PDX models and in a model of conditional CHECK1 knock-out in HCT116 cultured ovarian carcinoma cells; all other experimentally confirmed relationships that we tested (see previous subsection) were identified by all considered methods. Here, CHEK1 is linked to ovarian carcinoma.