It specifically binds to IGF-1R, triggering downstream mitogen-activated protein kinase (MAPK) and phosphoinosyl 3 kinase/protein kinase B(PI3K/Akt) signal transduction, thus regulating tumor cells growth, proliferation, invasion and metastasis (Sun et al., 2015; Spiliotaki et al., 2018). Here, AKT1 is linked to neoplasm.