Researchers have found that IGF-1R/IRS1 signaling pathway is also related to the adhesion process among malignant tumor cells, and plays an important role in the phenotype maintenance of cancer cells and the process of anti-tumor treatment resistance (Marconett et al., 2012; Yang et al., 2018; Luo et al., 2021). The gene discussed is IGF1R; the disease is cancer.