According to the significant role of IL-6/ STAT3 pathway in tumorigenesis of CCA (Rizvi and Gores, 2014; Roy et al., 2019), implying that LIN28B may partially involve in CCA initiation by inducing an inflammatory loop IL-6/STAT3 in cholangiocytes. The gene discussed is LIN28B; the disease is cholangiocarcinoma.