Moreover, LIN28B may implicate in other MOC by which LIN28B induces cholangiocyte secretion of many cytokines associated with ductular reaction which are known to promote apoptosis inhibition (MOC-5a) and cholangiocyte proliferation (MOC-5b) (Sato et al., 2019), those cytokines also play an important role in regulating immune cell activity in the tumor microenvironment (MOC-6) (Pinto et al., 2018). Here, LIN28B is linked to neoplasm.