According to the critical role of LIN28B in tumorigenesis, it was reported to be a tumor-initiating factor and sufficient to induce cancer development in multiple contexts in vivo, including lymphoma (Beachy et al., 2012), neuroblastoma (Molenaar et al., 2012), and liver cancer (Nguyen et al., 2014). The gene discussed is LIN28B; the disease is cancer.