LIN28B is likely promoted drug resistance by following themulti-factorials mechanistic of chemoresistance (MOCs) (Marin et al., 2018).The reduction of intracellular drug activity (MOC-2) is proposed by which LIN28B induces the detoxifying ALDH enzyme activity, which has been shown to reduce the effect of gemcitabine and drug resistance in CCA patients (Chen et al., 2016). Here, LDHA is linked to cholangiocarcinoma.