Pro-inflammatory cytokines like TGF-β (transforming growth factor beta), TNF-α (tumour necrosis factor alpha), interkeukins (IL) like IL-1β, and IL-6 (Interleukin) elevate the expression of selectins on the vascular cells, which synchronize with the IL-8 secreted by the tumor cells (Mantovani et al., 2008). Here, TNF is linked to neoplasm.