The expression of IL-1β; NF-κB1 and NLRP3 which are intracellular mediators are elevated in MPN subgroups as compared to controls (IL-1β; P=0.002; NF-κB1 P=≤0.001; NF-κB1 P=≤0.001; NLRP3 P=0.001). The gene discussed is NLRP3; the disease is myeloproliferative disorder.