Increasing neutrophils in cancer microenvironment known as Tumor Associated Neutrophils (TANs), plays important rules in tumor progressivity, by releasing factors that modulate the extracellular matrix and inflammation of the tumor microenvironment of , such as neutrophil elastase (NE), neutrophil collagenase (MMP-8), and gelatinase B (MMP-9) (Shen et al., 2014). Here, ELANE is linked to cancer.