CASP8 and colonic neoplasm: Lignan initiates apoptosis in cell cycle by inhibiting telomerase activity, bcl2 suppression and activating c-myc, caspase 3 and caspase 8 to cancer cell lines HepG2, E1-1 monocyte, HeLa and MCP7; while flavonoid has been proven to inhibit proliferation and induce apoptosis to human colon cancer line Ca-co2, HT-29, and SW480 (Sawitri et al, 2013; Jose et al, 2014; Loo 2003; Giridharan et al, 2002).