PRF1 and colorectal cancer: These results are in coherent with the study conducted by Endang et al, 2013, that shows immune system improvement through the escalation of lymphocyte infiltration, perforin expression by CTL and NK cells, apoptosis index, the suppression of cell perforation and colorectal cancer growth on Sprague-Dawley rats induced with 1.2 DMH (Sawitri et al., 2013).