S100A8 and adenocarcinoma: This is in agreement with Lins et al., (2016) and Pendely et al., (2018) who reported that cytoplasmic survivin positivity in precancerous lesions was strongly associated with cagA+ H. pylori infection and assists in preventing cell apoptosis, whereas nuclear survivin in adenocarcinomas may stimulate cell division frequently observed in advanced malignancy.