However, Sohrabi et al., in a case-control study evaluated the association of MTHFR A1298C and C677T variants among in 50 cervical intraepithelial neoplasia cases, 98 HPV-positive subjects and 47 non-cancerous/non-HPV patients as healthy controls. Here, MTHFR is linked to cervical intraepithelial neoplasia.