First of all, we found that the AIM2, CASP3, CASP4, CASP5, CASP6, CASP8, GSDMB, GSDMC, GZMB, IL18, NLRP2, NLRP7, NOD2, PYCARD, and TNF were significantly up-regulated in CC tissues, while ELANE, NLRP1, NOD1, and PJVK were significantly down-regulated (Figure 1A). This evidence concerns the gene IL18 and cholangiocarcinoma.