The levels of expression of GZMB were significantly and positively correlated with TMB in bladder urothelial carcinoma (BLCA), breast invasive carcinoma (BRCA), cervical squamous cell carcinoma, and endocervical adenocarcinoma (CESC orCC), CHOL, COAD, LGG, LUAD, STAD, and UCEC, Meanwhile, the correlation was significantly negative with kidney renal papillary cell carcinoma (KIRP) and thyroid carcinoma (THCA) (Figure 7B). The gene discussed is GZMB; the disease is thyroid gland carcinoma.