TNF and acute kidney injury: Treatment by cisplatin resultsin the reduction of Bcl-2 and BAX ratio, upregulationof apoptotic genes, degradation or decrease of anti-apoptotic proteins, and increase of pro-apoptotic proteinsand inflammatory mediators, such as TNF-α (34-38).Therefore, reduction of renal cell apoptosis is one of theimportant mechanisms to be considered in the treatmentof AKI.