SYP and neoplasm: Given the clinical relevance to rapidly developing metastases of the tumor, Perry et al. pointed the possibility that composite hemangioendotheliomas with neuroendocrine marker expression (mostly synaptophysin) might be better interpreted as representing a form of malignant progression in retiform and Dabska-type hemangioendotheliomas which are often positive for synaptophysin, or closely related to angiosarcomas [1].