Treg cells in adipose tissue express the enzyme hydroxyprostaglandin dehydrogenase (HPGD), which converts prostaglandin E2 (PGE2) into 15-keto PGE2, and Treg cell-specific loss of HPGD exacerbates adipose inflammation and insulin resistance in response to diet-induced obesity [47]. Here, HPGD is linked to Insulin resistance.