Variants predicted to be damaging and known or suspected to be compound heterozygous were identified in CDH23 [MIM: 605516] in Families 8, 21, 56 (father with HL), and 60 (mother with HL), MYO7A [MIM: 276903] in Family 56 (mother with HL), PCDH15 [MIM: 605514] in Family 5, and USH2A [MIM: 608400] in Family 29 (mother with HL) (Table 1, Supplementary Table 4, and Fig. 3b). The gene discussed is PCDH15; the disease is Hodgkins lymphoma.