In addition, two damaging homozygous variants were identified in TMPRSS3 [MIM: 605511, DFNB8/B10] (NM_024022.3:c.323-6G>A, a previously reported variant, and c.1363T>C, p.(Ter455ArgextTer9)) in one subject with HL in Family 40. Here, TMPRSS3 is linked to Hodgkins lymphoma.