Figure 3B shows the representative genes where stemness genes (GATA3 and ALDH3A1), genes driving EMT and chemoresistance (PIK3R2, PAK4 and TGFB1) were downregulated and known tumour suppressors (ATRX and ZBTB1) were upregulated in ST09 treated PA1 cells. The gene discussed is PAK4; the disease is neoplasm.