LRRK2 and Parkinson disease: In the PPMI cohort, 367 sporadic PD (sPD), 72 LRRK2 (G2019S) PD, 39 GBA (N370S) PD patients, and 213 controls were analyzed, and 38 sPD patients and 71 controls in the GSH cohort were investigated (see Fig. 1).