Finally, onset ages of DAT decline were similar between GBA PD, LRRK2 PD, and sPD groups in the present study, however, patients with the GBA N370S variant had more rapid deterioration of putaminal dopaminergic function during the premotor phase (Fig. 4c, d and Supplementary Table 1). This evidence concerns the gene LRRK2 and Parkinson disease.