Therefore, as shown in our estimation (Fig. 4d and Supplementary Table 1), it is possible that PD patients with the GBA N370S mutation may experience rapid progression of striatal dopaminergic dysfunction during the premotor stage, and consequently, the GBA N370S variant may be associated with disease manifestation at a younger age and earlier diagnosis of PD compared to sporadic cases31. The gene discussed is GBA1; the disease is Parkinson disease.