LRRK2 and Parkinson disease: The early-onset PD (EOPD) group had significantly higher GRS than late-onset PD (LOPD) patients (EOPD 6.371 ± 0.609 vs. LOPD 6.068 ± 0.668; independent t-test, p = 0.004), while LRRK2 and GBA PD patients had significantly longer disease duration than the sPD group (Mann-Whitney U test, p < 0.001), but AAO did not show a significant difference between the two genetic PD (gPD) groups.