CD226 and glioblastoma: The pathways enriched in GBM.pembro included: TIGIT:CD226:NECTIN2, CD86:CTLA4, PDCD1:PD-L1/L2, Type II IFN (IFN-γ), CXCL:CXCR, XCR:XCL, and CCR:CCL (Fig. 6b).