To further explore whether microglia/macrophages and astrocytes engulf synapses through MEGF10 and MERTK at the repair and remodeling stages after stroke, we analyzed the phagocytosis of microglia/macrophages and astrocytes by using astrocyte-specific MEGF10 knockout mice (Aldh1l1Cre-ERT2; MEGF10flox/flox), astrocyte-specific MERTK knockout mice (Aldh1l1Cre-ERT2; MERTKflox/flox), microglia/macrophage-specific MEGF10 knockout mice (CX3CR1Cre-ERT2; MEGF10flox/flox) and microglia/macrophage-specific MERTK knockout mice (CX3CR1Cre-ERT2; MERTKflox/flox). This evidence concerns the gene MEGF10 and stroke disorder.