SYP and ischemic stroke: We found that 14 days after ischemic stroke, MEGF10KO or MERTKKO in microglia/macrophages or astrocytes resulted in reduced engulfment of SYP+ and Homer-1+ synaptic puncta in microglia/macrophage (Fig. 5a, b) or astrocytes (Fig. 5c, d) compared with controls.