By quantifying SMI32+/MBP+-damaged myelinated axons, we concluded that knockout of MEGF10 or MERTK decreased axonal degeneration in the ischemic mouse brain but not in the hemorrhagic mouse brain, suggesting that in addition to protecting synapses, genetic manipulation of MEGF10 or MERTK also reduces axonal degeneration in ischemic stroke (Supp. The gene discussed is MEGF10; the disease is ischemic stroke.