Partial inhibition of the proapoptotic UPR mediated by PERK contributes to tumorigenesis and tumor progression.13,15,16 However, PERK inhibition has also been reported to sensitize cancer cells to chemotherapeutic drugs.21,44,45 Since paclitaxel and 5-FU are the first-line chemotherapeutic drugs for NPC and cervical cancer patients,46,47 we tested if DNA tumor virus could chemo-sensitize cancer cells via inhibition of PERK activity, thereby leading to a favorite prognosis. This evidence concerns the gene EIF2AK3 and cervical cancer.