PERK also is involved in regulation of oxidative stress.9 ROS may potentially be deleterious or beneficial for cancer cells, depending on the amount of ROS production.22–25 A appropriate increase in ROS promotes cancer cell proliferation and tumor formation by inducing redox-dependent and pro-oncogenic signaling pathways,26,27 whereas excessive amounts of ROS result in oxidative damage to macromolecular, including lipids, proteins, and DNA, to trigger cancer cell death.28,29 Thus, a tightly controlled redox balance is critical for cancer cells function and survival. Here, EIF2AK3 is linked to cancer.