For instance, LOXL2 facilitates intrahepatic metastasis by crosslinking extracellular matrix components in the liver to promote cytoskeletal remodeling [29]; LOXL2 interacts and cooperates with Snail to downregulate E-cadherin expression, thus inducing epithelial-to-mesenchymal transition (EMT) to drive carcinoma progression [33]. This evidence concerns the gene SNAI1 and carcinoma.