CD4 and cancer: Because the activities of cancer immunity cycles are directly determined by the comprehensive performance of immunomodulators, the activities of most cancer immunity cycles were downregulated in 5mC cluster 1, such as the release of cancer cell antigens (Step 1), trafficking of immune cells to tumors (Step 4) (CD8 T cell recruitment, CD4 T cell recruitment, macrophage recruitment, Th1 cell recruitment, NK cell recruitment, DC recruitment), and killing of cancer cells (Step 7) (Figs. 3A, S15C).