A majority of 5mC regulators were expressed explicitly on cancer cells, such as DNMT3A, MBD1, MBD3, UNG, NEIL1, ZBTB33, NTHL1, SMUG1, TDG, UHRF1, TET1, TET2, and TET3 (Fig. S3). The gene discussed is UHRF1; the disease is cancer.