IL22 and airway hyperresponsiveness: Besides, in IL-22-deficient (IL-22−/−) mice or administration anti-IL-22 antibody wild-type (WT) mice, allergic airway inflammation and airway hyperresponsiveness (AHR) was aggravated, manifested as an enhanced proportion of eosinophils in bronchoalveolar lavage fluid (BALF), exacerbated inflammatory cell infiltration around the bronchi and their concomitant vessels, increased airway responsiveness and cytokine production [9, 19, 20], indicating the protective role of IL-22 in allergic airway inflammation.