In this study, we have compared the expression level of IL-22 in OVA-induced mice and control mice, explored the effect of IL-22 on allergic asthma, and found that the IL-22 level significantly increased in lung tissues of the OVA-induced mice and IL-22 showed anti-inflammation properties in allergic asthma, attenuating airway inflammation and airway hyperresponsiveness. Here, IL22 is linked to airway hyperresponsiveness.