ALK and non-small cell lung carcinoma: The efficacy of crizotinib as the first-line treatment for patients with advanced ALK-rearranged NSCLC was proved in PROFILE 1014 [6, 25], however, novel-generation ALK-TKIs in the first-line setting have shown improved PFS versus crizotinib [10, 11, 13, 26–31, 33, 34].