Moreover, the results of genetic studies of humans suggest the association of obesity-related HTN with the variants of several genes involved in aldosterone secretion and metabolism, such as glucocorticoid receptor, aldosterone synthase (CYP11B2), and serum and glucocorticoid-regulated kinase 1 [90,91,92]. The gene discussed is CYP11B2; the disease is obesity due to melanocortin 4 receptor deficiency.