By contrast, low magnesium levels could result in impaired insulin action as well as an altered cellular glucose transport, which promotes peripheral IR in T2DM [111], and its dietary supplementation may reduce the risk of T2DM-associated CVD due to a favorable effect on HDL, LDL, fasting plasma glucose, C-reactive protein (CRP), and insulin [112,113]. This evidence concerns the gene INS and type 2 diabetes mellitus.