In particular, a double-blind randomized cross-over trial [32], which investigated the effects of magnesium supplementation on metabolic control and insulin sensitivity in 98 type 2 diabetic patients, did not find magnesium supplementation to have any significant improvement in the fasting glucose, HbA1c, insulin, or homeostatic model assessment—insulin resistance (HOMA-IR) of the patients. The gene discussed is INS; the disease is Insulin resistance.