Therefore, taking into account the significant impact of this global public health problem and its adverse outcomes, the aim of this randomized clinical trial was to analyze the effectiveness of two nutritional interventions, i.e., EVOO and the traditional Brazilian diet (DieTBra) in reducing the NLR, LMR, leukocytes, and the CRP of individuals with severe obesity. This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.