It covers three items: food protein-induced enterocolitis syndrome (FPIES), food protein-induced allergic proctocolitis (FPIAP), and food protein-induced enteropathy syndrome (FPIE) as well as the syndrome of eosinophilic gastrointestinal diseases (EGID), where milk can cause allergic reactions under the IgE-dependent and IgE-independent mechanism. This evidence concerns the gene IGHE and eosinophilic gastrointestinal disease.