RIG-I was found to be activated by positive- and negative-stranded RNA viruses such as influenza, Rift Valley fever, measles, Ebola, vesicular stomatitis, and hepatitis C viruses [62], whereas MDA5 was found to be activated by picornavirus, arteriviruses, hepatitis D, encephalomyocarditis, and Kaposi’s sarcoma-associated herpesvirus [63,64,65,66]. The gene discussed is IFIH1; the disease is influenza.