Furthermore, the aging-induced upregulation of the cyclin-dependent kinase-4 (cdk4) phosphorylates CCAAT enhancer-binding protein (C/EBP α) and formation of C/EBPa-p300 complexes causing steatosis, and CDK-4 inhibition, was shown to lower steatosis [137,140]. The gene discussed is CDK4; the disease is steatosis.