In addition to the aforementioned SNPs, the Gly385Arg polymorphism in fibroblast growth factor receptor 4 (FGFR4) was not linked to liver fat content or insulin sensitivity in 170 subjects with overweight/obesity at baseline, but it was associated with less decrease in liver fat accumulation and insulin sensitivity under healthy dietary conditions [74]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.