PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Importantly, genome-wide association studies (GWAS) and candidate gene studies have revealed, in the last few years, that NAFLD development, severity and risk of progression are strongly influenced by a number of single-nucleotide polymorphisms (SNPs), including patatin-like phospholipase domain-containing protein 3 (PNPLA3), transmembrane 6 superfamily member 2 (TM6SF2), membrane bound O-acyltransferase domain containing 7 (MBOAT7), glucokinase regulatory protein (GKRP) and hydroxysteroid 17-βdehydrogenase 13 (HSD17B13) as the main genetic determinants of NAFLD [8].