Our recent animal experiments also showed that IJH-SONE68-derived EPSs prevent and improve picryl chloride-induced contact dermatitis and dextran sulfate sodium (DSS)-induced ulcerative colitis on model mice, by repressing the accelerated expression of interleukin (IL)-4 and the serum IgE level [26] and by reducing the MIP-2 expression [27], respectively. Here, IGHE is linked to contact dermatitis.