There are studies demonstrating that activation of ERβ was involved in the prevention and treatment of cancer progression by modulating the PI3K–protein kinase B (Akt)/mTOR signaling pathway [17,18,19]; however, the functions of ERβ and the correlation between ERβ and Akt/mTOR in regulating hepatic lipid metabolism are not yet clear. The gene discussed is MTOR; the disease is cancer.