Studies conducted on male C57BL/6 mice in whom hyperglycemia was induced with streptozotocin showed an increase in MDA and a decrease in total antioxidant capacity (TAC), SOD total, SOD2 (Mn-dependent SOD), and the GSH/GSSG (glutathione disulfide) ratio in the endothelium [67]. This evidence concerns the gene SOD2 and Hyperglycemia.