On the other hand, it could be argued that in a scenario of chronic renal failure 25(OH)D3 is not efficiently converted to the active form 1α,25(OH)2D3, and patients have been reported displaying normal values of 25(OH)D3 levels (26 ng/mL) and hugely increased IL-6 concentrations (580 pg/mL). The gene discussed is IL6; the disease is chronic kidney disease.