The colons derived from ALS-treated mice displayed a significant increase in key markers of goblet cell differentiation including the SAM pointed domain containing the ETS transcription factor (Spdef) promoting the maturation of the goblet, Kruppel-like factor 4 (Klf4) regulating goblet cell differentiation, and fucosyltransferase 2 (Fut2) encoding fucosyltransferase on the glycosylation of mucins (Figure 3A–C). The gene discussed is SPDEF; the disease is amyotrophic lateral sclerosis.