Comparing PCOS patients MHO with MUO patients, the latter had the highest BMI and WC values (p < 0.001), higher levels of inflammation (p < 0.001), testosterone (p < 0.001), and insulin (p < 0.001), worst metabolic parameters, highest cardio-metabolic indices (p < 0.001), multiple clusters of the MetS (p < 0.001), and higher Ferriman-Gallwey score values (p < 0.001). This evidence concerns the gene INS and metabolic syndrome.