AKT1 and early-onset autosomal dominant Alzheimer disease: In order to determine whether the soluble epoxide hydrolase inhibitor (sEHI) could inhibit the seemingly deleterious molecular effects of the HGD on hippocampal microvessels (upregulation of genes in pathways such as PPAR signaling, PI3K-Akt signaling that play an important role in oxidative stress, inflammation and Alzheimer’s disease), we again performed hierarchical clustering of global gene expression profiles for the LGD and the HGD in the presence of the inhibitor (Figure 5).