PPARA and early-onset autosomal dominant Alzheimer disease: This analysis indeed revealed differential regulation of 5 key cellular pathways including for neurodegenerative diseases (such as Alzheimer’s disease), cell signaling pathways (such as PPAR signaling and phosphoinositide-3-kinase-protein kinase B (PI3K-Akt) signaling), cell adhesion and mobility (including focal adhesion), cellular metabolism (including oxidative phosphorylation and electron transport chain), and other cellular pathways (such as mRNA processing and oxidative damage) (Figure 4B and 4C).