The most statistically significant transcription factors were STAT3 (Signal Transducer and Activator of Transcription 3) involved in focal adhesion, DNMT1 (DNA Methyl Transferase 1), and PPARA (Peroxisome Proliferator-Activated Receptor Alpha) involved in Alzheimer’s disease (Supplemental Table S2). Here, PPARA is linked to early-onset autosomal dominant Alzheimer disease.