Furthermore, they showed that among the teenagers with HOMA-IR > 3.0, the increase of one point in the BMI z-score was accompanied by a loss of 70 mL in FEV1 (p for interaction= 0.0006) and by a significant decline in FEV1/FVC (p for interaction= 0.02), which did not happen in the non-insulin-resistant patients; therefore the synergic action of obesity and insulin resistance could contribute to the dysanapsis and thus to the development of asthma or, at least, to worsen it [69]. This evidence concerns the gene INS and asthma.