LEP and obesity due to melanocortin 4 receptor deficiency: Conversely, obesity has also been related with increased bronchial hyperreactivity: the maximum fall in FEV1 after exercise was significantly greater among obese asthmatics than among non-obese asthmatics and that the leptin plasma levels, significantly more elevated in obese subjects, were related with the risk of exercise-induced bronchospasm (OR = 1.21; 95% CI: 0.027–1.335) [51]; the risk of exercise-induced bronchospasm is thus higher the higher the BMI is [52].