A metanalysis published in 2017 [61] found asthma diagnosis to be associated with elevated levels of leptin in adults (standardised difference in means = 1.37, 95% CI 0.62 to 2.13, p < 0.001) and in children (standardised difference in means = 0.30, 95% CI 0.01 to 0.59, p = 0.042) and low levels of adiponectin in adults, but not in children. This evidence concerns the gene LEP and asthma.